Recombinant Human EGR1 (N-6His)

Description

EnkiLife provides the Recombinant Human EGR1 (N-6His) protein,aslo know as EGR-1,Early growth response protein 1,Zif268,zinc finger protein 225, NGFI-A ,nerve growth factor-induced protein A;, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Early Growth Response Protein 1 is produced by our E.coli expression system and the target gene encoding Gln282-Ser433 is expressed with a 6His tag at the N-terminus.Accession:P18146. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:19.9 KDa. Background:EGR-1 belongs to the EGR family of C2H2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. EGR-1 recognizes and binds to the DNA sequence 5-CGCCCCCGC-3(EGR-site).The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumor suppressor gene. EGR-1 has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity. EGR-1 has also been found to regulate the expression of synaptobrevin II (a protein important for synaptic exocytosis).