Recombinant Human ENO2 (N-6His)

Description

EnkiLife provides the Recombinant Human ENO2 (N-6His) protein,aslo know as Gamma-enolase,2-phospho-D-glycerate hydro-lyase,Enolase 2,Neural enolase,Neuron-specific enolase,NSE,ENO2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Gamma-enolase is produced by our E.coli expression system and the target gene encoding Met1-Leu434 is expressed with a 6His tag at the N-terminus.Accession:P09104. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:49.4 KDa. Background:Gamma-enolase, also known as Enolase 2, belongs to the enolase family. The alpha/alpha homodimer of ENO2 is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells. Levels of ENO2 increase dramatically in cardiovascular accidents, cerebral trauma, brain tumors and Creutzfeldt-Jakob disease. ENO2 has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. It binds to cultured neocortical neurons and promotes cell survival in a calcium-dependent manner.