Recombinant Human ENPP-2 (C-6His)

Description

EnkiLife provides the Recombinant Human ENPP-2 (C-6His) protein,aslo know as ATX,ATXFLJ26803,ATX-X,Autotaxin,autotaxin-t,EC 3.1.4.39,ectonucleotide pyrophosphatase/phosphodiesterase 2,E-NPP 2,ENPP2,LysoPLD,NPP2,PD-IALPHA,PDNP2,PDNP2NPP2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 is produced by our Mammalian expression system and the target gene encoding Ala36-Ile863 is expressed with a 6His tag at the C-terminus.Accession:AAH34961.1. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:96 KDa. Background:ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain.Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung.