Recombinant Human ER alpha (N-6His)

Description

EnkiLife provides the Recombinant Human ER alpha (N-6His) protein,aslo know as Estrogen Receptor,ER,ER-Alpha,Estradiol Receptor,Nuclear Receptor Subfamily 3 Group A Member 1,ESR1,ESR,NR3A1,Estrogen Receptor Alpha,ER alpha,estrogen receptor alpha, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Estrogen Receptor Alpha is produced by our E.coli expression system and the target gene encoding Met1-Gln116 is expressed with a 6His tag at the N-terminus.Accession:P03372. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:14.38 KDa. Background:Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5 UTRs and use different promoters.