Recombinant Human FAM3B (C-Fc)

Description

EnkiLife provides the Recombinant Human FAM3B (C-Fc) protein,aslo know as C21orf11,Cytokine-like protein 2-21,D21M16SJHU19e,FAM3B,family with sequence similarity 3, member B,ORF9,pancreatic derived factor,Pancreatic-derived factor,PANDER,PRED44, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Protein FAM3B is produced by our Mammalian expression system and the target gene encoding Glu30-Ser235 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:P58499. Expression Host:Human Cells.Species:Human .Predicted Molecular Mass:50 KDa. Background:FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.