Recombinant Human FGFa (140AA)

Description

EnkiLife provides the Recombinant Human FGFa (140AA) protein,aslo know as Fibroblast Growth Factor 1,FGF-1,Acidic Fibroblast Growth Factor,aFGF,Endothelial Cell Growth Factor,ECGFHeparin-Binding Growth Factor 1,HBGF-1,FGF1,FGFA, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Fibroblast Growth Factor 1/Fibroblast Growth Factor Acidic is produced by our E.coli expression system and the target gene encoding Phe16-Asp155 is expressed.Accession:P05230. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:16 KDa. Background:FGF acidic, also known as ECGF, FGF-1and HBGF-1, is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. It is a mitogenic peptide that is produced by multiple cell types and stimulates the proliferation of cells of mesodermal, ectodermal, and endodermal origin. Its association with heparan sulfate is a prerequisite for activation of FGF receptors. Internalized FGF acidic migrates to the nucleus where it is phosphorylated by nuclear PKC delta, exported to the cytosol, dephosphorylated, and degraded. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling.