Recombinant Human FGFR2IIIb (C-6His)

Description

EnkiLife provides the Recombinant Human FGFR2IIIb (C-6His) protein,aslo know as BFR-1,FGFR2IIIb,KGFR,CD332,FGF R2b,FGFR2 beta,FGFR2,FGFR2b, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Fibroblast growth factor receptor 2 (IIIb) is produced by our Mammalian expression system and the target gene encoding Arg152-Glu378 is expressed with a 6His tag at the C-terminus.Accession:P21802-3. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:26.2 KDa. Background:FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGF R3 and FGF R4. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.