Recombinant Human FLT3 (C-Fc)

Description

EnkiLife provides the Recombinant Human FLT3 (C-Fc) protein,aslo know as Receptor-Type Tyrosine-Protein Kinase FLT3,FL Cytokine Receptor,Fetal Liver Kinase-2,FLK-2,Fms-Like Tyrosine Kinase 3,FLT-3,Stem Cell Tyrosine Kinase 1,STK-1,CD135,FLT3,FLK2,STK1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Receptor-Type Tyrosine-Protein Kinase FLT3/FLT3 is produced by our Mammalian expression system and the target gene encoding Asn27-Asn541 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:AAI26351.1. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:85.3 KDa. Background:The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2and Stk-1is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the receptor for SCF and FMS, the receptor for M-CSF. The extracellular region of these receptors contains five immunoglobulin-like domains and the intracellular region contains a split kinase domain. Human Flt-3 cDNA encodes a 993 amino acid (aa) residue type I membrane protein with a 26 aa residue signal peptide, a 515 aa extracellular domain with 10 potential N-linked glycosylation sites, a 21 aa residue transmembrane domain and a 431 aa residue cytoplasmic domain. Flt-3 expression has been detected in various tissues, including placenta, gonads, and tissues of nervous and hematopoietic origin. Among hematopoietic cells, the expression of Flt-3 was found to be restricted to the highly enriched stem/progenitor cell populations. The ligand for Flt-3 (FL) has been identified to be a transmembrane protein with structural homology to M-CSF and SCF. Recombinant soluble Flt-3/Fc chimeric protein has been shown to bind FL with high affinity and is a potent FL antagonist.