Recombinant Human G-CSFR (C-Fc)

Description

EnkiLife provides the Recombinant Human G-CSFR (C-Fc) protein,aslo know as CD114 antigen,CD114,colony stimulating factor 3 receptor (granulocyte),CSF3R,Csfgr,G-CSF R,G-CSF receptor,GCSFR,G-CSFR,GCSFRG-CSF-R, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Granulocyte Colony-stimulating Factor Receptor is produced by our Mammalian expression system and the target gene encoding Glu25-His627 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q99062. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:93.7 KDa. Background:Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, the protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.