Recombinant Human GABARAP (N-GST)

Description

EnkiLife provides the Recombinant Human GABARAP (N-GST) protein,aslo know as GABA(A) Receptor-Associated Protein,GABARAP Protein,HCG1987397 Isoform CRA_b,GABARAP, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human GABA (A) Receptor-Associated Protein is produced by our E.coli expression system and the target gene encoding Met1-Leu117 is expressed with a GST tag at the N-terminus.Accession:Q6IAW1. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:40.21 KDa. Background:Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter, GABA, acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.