Recombinant Human GADD45A (N-6His)

Description

EnkiLife provides the Recombinant Human GADD45A (N-6His) protein,aslo know as Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha,DNA Damage-Inducible Transcript 1 Protein,DDIT-1,GADD45A,DDIT1,GADD45, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Growth Arrest And DNA Damage-Inducible Protein GADD45 alpha is produced by our E.coli expression system and the target gene encoding Met1-Arg165 is expressed with a 6His tag at the N-terminus.Accession:P24522. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:20.5 KDa. Background:Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation, X-rays, growth arrest and alkylating agents, of which can be mediated by some kinases other than PKC. GADD45A can interact with MAPK14, GADD45GIP1, PCNA. In T-cells, GADD45A functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. GADD45A may affect PCNA interaction with some cell division protein kinase complexes, stimulating DNA excision repair in vitro and inhibits entry of cells into S phase.