Recombinant Human GALNT3 (C-6His)

Description

EnkiLife provides the Recombinant Human GALNT3 (C-6His) protein,aslo know as Polypeptide N-acetylgalactosaminyltransferase 3,Polypeptide GalNAc transferase 3,GalNAc-T3,pp-GaNTase 3,Protein-UDP acetylgalactosaminyltransferase 3,UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3,HFTC,HHS, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 3 is produced by our Mammalian expression system and the target gene encoding Gln38-Asp633 is expressed with a 6His tag at the C-terminus.Accession:Q14435. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:69.1 KDa. Background:Polypeptide N-acetylgalactosaminyltransferase 3(GALNT3) belongs to the glycosyltransferase 2 family and galNAc-T subfamily. It expressed in organs that contain secretory epithelial glands and it highly expressed in pancreas, skin, kidney and testis. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding .This protein plays a major role in regulating phosphate levels within the body (phosphate homeostasis). Among its many functions, phosphate plays a critical role in the formation and growth of bones in childhood and helps maintain bone strength in adults.