Recombinant Human Gankyrin

Description

EnkiLife provides the Recombinant Human Gankyrin protein,aslo know as 26S Proteasome Non-ATPase Regulatory Subunit 10,26S Proteasome Regulatory Subunit p28,Gankyrin,p28(GANK),PSMD10, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Gankyrin is produced by our E.coli expression system and the target gene encoding Met1-Gly226 is expressed.Accession:O75832. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:24.43 KDa. Background:Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.