Recombinant Human GFRA2 (C-6His)

Description

EnkiLife provides the Recombinant Human GFRA2 (C-6His) protein,aslo know as GDNF Family Receptor Alpha-2,GDNF Receptor Alpha-2,GDNFR-Alpha-2,GFR-Alpha-2,GDNF Receptor Beta,GDNFR-Beta,Neurturin Receptor Alpha,NRTNR-Alpha,NTNR-Alpha,RET Ligand 2,TGF-Beta-Related Neurotrophic Factor Receptor 2,GFRA2,GDNFRB,RETL2,TRNR2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Glial Cell line-derived Neurotrophic Factor Receptor Alpha 2 is produced by our Mammalian expression system and the target gene encoding Ser22-Ser441 is expressed with a 6His tag at the C-terminus.Accession:O00451. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:47.79 KDa. Background:Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and Neurturin, play key roles in the control of vertebrate neuronal survivial and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2, and GFRα-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFRα-1 and GFRα-2 have been shown to mediate the GDNF-dependent and Neurturin-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR-3 is expressed only during development. GFRα-2 binds Neurturin and mediates activation of RET receptor tyrosine kinase by both Neurturin and GDNF.