Recombinant Human GITR (C-mFc)

Description

EnkiLife provides the Recombinant Human GITR (C-mFc) protein,aslo know as Tumor necrosis factor receptor superfamily member 18,TNFRSF18,Glucocorticoid-induced TNFR-related protein,CD357,TNFRSF18,AITR,GITR, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant human Glucocorticoid Induced TNF Receptor Family Related Gene is produced by our Mammalian expression system and the target gene encoding Gln26-Glu161(Thr45Ala) is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:Q9Y5U5. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:41.1 KDa. Background:Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.