Recombinant Human GRB2 (C-6His)

Description

EnkiLife provides the Recombinant Human GRB2 (C-6His) protein,aslo know as Growth Factor Receptor-Bound Protein 2,Adapter Protein GRB2,Protein Ash,SH2/SH3 Adapter GRB2,GRB2,ASH, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Growth Factor Receptor-Bound Protein 2 is produced by our E.coli expression system and the target gene encoding Met1-Val217 is expressed with a 6His tag at the C-terminus.Accession:P62993. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:26.3 KDa. Background:As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted action of both its SH2 and SH3 domains.