Recombinant Human GSN (C-mFc)

Description

EnkiLife provides the Recombinant Human GSN (C-mFc) protein,aslo know as Gelsolin,GSN,AGEL,Actin-depolymerizing factor,ADF,Brevin, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Gelsolin is produced by our Mammalian expression system and the target gene encoding Ala28-Ala782 is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:P06396. Expression Host:Human cells.Species:Human.Predicted Molecular Mass:109.3 KDa. Background:Gelsolin is a calcium-activated actin filament severing and capping protein found in many cell types and as a secreted form in the plasma of vertebrates. Gelsolin is composed of six of these domains, termed G1-6. Some reaseraches show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. The difference in the expression levels of cytoplasmic and plasma gelsolin suggests that these two different forms of gelsolin may play different roles after cardiac injury. Plasma gelsolin, as an important component of the EASS, may have evolved to rapidly clear actin filaments from the circulation that are released by injured or dead cells.