Recombinant Human GUCY2C (C-6His)

Description

EnkiLife provides the Recombinant Human GUCY2C (C-6His) protein,aslo know as Heat-stable enterotoxin receptor,GUCY2C,STA receptor,hSTAR,Guanylyl cyclase C,GC-C,Intestinal guanylate cyclase,GUC2C,STAR, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Guanylyl Cyclase C is produced by our Mammalian expression system and the target gene encoding Ser24-Gln430 is expressed with a 6His tag at the C-terminus.Accession:P25092. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:46.8 KDa. Background:GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type/xa0I transmembrane protein of the guanylate cyclase (gc) family. GUCY2C cell surface expression is confined to luminal surfaces of the intestinal epithelium and a subset of hypothalamic neurons. The inaccessibility of GUCY2C in the apical membranes of polarized epithelial tissue, due to subcellular restriction of GUCY2C, creates a therapeutic opportunity to target metastatic lesions of colorectal origin which have lost apicalbasolateral polarization without concomitant intestinal toxicity. And that CAR-T cells targeting murine GUCY2C were effective against colorectal cancer metastatic to lung in the absence of intestinal toxicities. Human GUCY2C-targeted CAR that could potentially be employed in patients with GUCY2C-expressing gastrointestinal malignancies.