Recombinant Human GUSB  (C-6His)

Description

EnkiLife provides the Recombinant Human GUSB  (C-6His) protein,aslo know as Beta-glucuronidase,GUSB,Beta-G1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Beta-glucuronidase is produced by our Mammalian expression system and the target gene encoding Leu23-Thr651 is expressed with a 6His tag at C-terminus.Accession:P08236. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:73.6 KDa. Background:Beta-glucoronidase is a lysosomal enzyme catylysing the decomposition of beta-D-glucoronides-compounds arising as a result of the combination of beta-D-glucoronic acid and a number of compounds both exo- and endogenous, containing hydroxylic, carboxylic, amine, imine or thiol groups. Beta-glucuronidase (βGLU)-a lysosomal acid hydrolase responsible for the catalytic deconjugation of β-D-glucuronides has emerged as a viable molecular target for several therapeutic applications. The enzymes activity level in body fluids is also deemed a potential biomarker for the diagnosis of some pathological conditions. The activity of beta-glucoronidase increases in many pathological conditions: liver infammations, cirrhosis of the liver, inflammations of other organs, cholestatic jaundice, tuberculosis, sarcoidosis and also in neoplasms. And many authors point to beta-glucoronidase as a sensitive indicator signalling cell damage.