Recombinant Human HER3 (C-mFc)

Description

EnkiLife provides the Recombinant Human HER3 (C-mFc) protein,aslo know as Proto-oncogene-like protein c-ErbB-3,Tyrosine kinase-type cell surface receptor HER3,ERBB3,HER3, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Receptor Tyrosine-Protein Kinase ErbB-3 is produced by our Mammalian expression system and the target gene encoding Ser20-Thr643 is expressed with a mouse IgG1 Fc tag at the C-terminus.Accession:P21860. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:95.1 KDa. Background:Receptor tyrosine-protein kinase erbB-3 is an enzyme that in humans is encoded by the ERBB3 gene. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB3 belongs to the protein kinase superfamily,tyr protein kinase family and EGF receptor subfamily.It contains 1 protein kinase domain and it is expressed in Epithelial tissues and brain. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity.