Recombinant Human HLA-A*0201 TP53 complex Protein (C-10His)

Description

EnkiLife provides the Recombinant Human HLA-A*0201 TP53 complex Protein (C-10His) protein,aslo know as MHC, HLA-A*0201 TP53 complex Protein, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human HLA-A*0201 TP53 complex Protein is produced by our Mammalian expression system and the target gene encoding (HMTEVVRHC)(R175H)&Ile21-Met119&Gly25-Ile308 (Ala269Val) is expressed with a 10His tag at the C-terminus.Accession:P61769&A0A140T913. Expression Host:Human cells.Species:Human.Predicted Molecular Mass:49.1 KDa. Background:Cellular tumor antigen p53, is also known as TP 53, is the most frequently mutated gene across all cancers and encodes the tumor suppressor p53 protein. There is a neoepitope of TP53 which is p53R175H HMTEVVRHC. TP53 protein is degraded by the proteasome into peptides, some of which can be presented on the cell surface by human leukocyte antigen (HLA). The p53R175H /HLA-A*02:01 complex is a particularly attractive therapeutic target, shared by many cancer patients.