Recombinant Human HPGD (C-6His)

Description

EnkiLife provides the Recombinant Human HPGD (C-6His) protein,aslo know as 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)],15-PGDH,Prostaglandin Dehydrogenase 1,HPGD,PGDH1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)]/HPGD is produced by our Mammalian expression system and the target gene encoding Met1-Gln266 is expressed with a 6His tag at the C-terminus.Accession:P15428. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:30 KDa. Background:15-hydroxyprostaglandin dehydrogenase [NAD(+, also known as Prostaglandin dehydrogenase 1, 15-PGDH, HPGD and PGDH1, belongs to the short-chain dehydrogenases/reductases (SDR) family. HPGD localizes to the cytoplasm and can be found in colon epithelium, existing as a homodimer. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. HPGD is down-regulated by cortisol, dexamethasone and betamethasone, up-regulated by TGFB1. HPGD inhibits in vivo proliferation of colon cancer cells. HPGD is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation.