Recombinant Human ICOS (C-Fc)

Description

EnkiLife provides the Recombinant Human ICOS (C-Fc) protein,aslo know as Inducible T-cell costimulator;activation-inducible lymphocyte immunomediatory molecule,CD278,AILIM,CVID1;ICOS;, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Inducible T-cell Costimulator is produced by our Mammalian expression system and the target gene encoding Glu21-Phe141 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q9Y6W8. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:40.9 KDa. Background:Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige