Recombinant Human IDH1 (C-8His)

Description

EnkiLife provides the Recombinant Human IDH1 (C-8His) protein,aslo know as Isocitrate Dehydrogenase [NADP] Cytoplasmic,IDH,Cytosolic NADP-Isocitrate Dehydrogenase,IDP,NADP(+)-Specific ICDH,Oxalosuccinate Decarboxylase,IDH1,PICD, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Isocitrate Dehydrogenase [NADP] Cytoplasmic is produced by our E.coli expression system and the target gene encoding Met1-Leu414 is expressed with a 8His tag at the C-terminus.Accession:O75874. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:48.1 KDa. Background:Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1) belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 exists as a homodimer, binding one magnesium or manganese ion per subunit. Mutations of IDH1 have been shown to cause metaphyseal chondromatosis with aciduria and are involved in the development of glioma IDH plays a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the α-hydroxylation of phytanic acid.