Recombinant Human IL-17RA (C-6His)

Description

EnkiLife provides the Recombinant Human IL-17RA (C-6His) protein,aslo know as IL17R,interleukin-17 receptor A,interleukin 17 receptor A,IL17RA;CD217, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Interleukin-17 Receptor A is produced by our Mammalian expression system and the target gene encoding Leu33-Trp320 is expressed with a 6His tag at the C-terminus.Accession:Q96F46. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:34.5 KDa. Background:CD217, also known as Interleukin-17 receptor A, is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F, it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6. The signaling events of IL 17 includes activation of NF kappa B and JNK, and require TNF receptor associated factors 6 (TRAF6) in the signaling pathway.