Recombinant Human IL-17RB (C-6His)

Description

EnkiLife provides the Recombinant Human IL-17RB (C-6His) protein,aslo know as Interleukin-17 receptor B,IL-17RB,CRL4,EVI27,IL17BR, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Interleukin-17 receptor B is produced by our Mammalian expression system and the target gene encoding Arg18/xadGly289 is expressed with a 6His tag at the C-terminus.Accession:Q9NRM6. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:30.7 KDa. Background:IL17RB(Interleukin-17 receptor B)is a receptor for the proinflammatory cytokines IL17B and IL17E. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta.Human IL-17B R cDNA encodes a 502 amino acid (aa) residue type I membrane protein with a putative 17 aa signal peptide, a 275 aa extracellular domain, a 21 aa transmembrane domain and a 189 aa cytoplasmic tail.The protein Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis.It’s reported that IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer.