Recombinant Human IL-1R2 (C-6His)

Description

EnkiLife provides the Recombinant Human IL-1R2 (C-6His) protein,aslo know as Interleukin-1 receptor type 2,IL-1R-2,IL-1RT-2,IL-1RT2,CD121 antigen-like family member B,CDw121b,IL-1 type II receptor,Interleukin-1 receptor beta,IL-1R-beta,Interleukin-1 receptor type II,CD121b, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Interleukin-1 Receptor Type 2/IL-1R-2 is produced by our Mammalian expression system and the target gene encoding Phe14-Glu343 is expressed with a 6His tag at the C-terminus.Accession:P27930. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:38.6 KDa. Background:Interleukin-1 receptor type 2 (IL1R2) belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 receptor type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signaling receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.