Recombinant Human IL-1RAcP (C-6His)

Description

EnkiLife provides the Recombinant Human IL-1RAcP (C-6His) protein,aslo know as Interleukin-1 Receptor Accessory Protein,IL-1 Receptor Accessory Protein,IL-1RAcP,Interleukin-1 Receptor 3,IL-1R-3,IL-1R3,IL1RAP,C3orf13,IL1R3, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Interleukin-1 Receptor Accessory Protein is produced by our Mammalian expression system and the target gene encoding Ser21-Glu359 is expressed with a 6His tag at the C-terminus.Accession:Q9NPH3. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:39.9 KDa. Background:Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1α, IL1βand IL33. IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. In addition, IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.