Recombinant Human IL-36RA

Description

EnkiLife provides the Recombinant Human IL-36RA protein,aslo know as Interleukin-36 Receptor Antagonist Protein,FIL1 Delta,IL-1-Related Protein 3,IL-1RP3,Interleukin-1 HY1,IL-1HY1,Interleukin-1 Delta,IL-1 Delta,Interleukin-1 Family Member 5,IL-1F5,Interleukin-1 Receptor Antagonist Homolog 1,IL-1ra Homolog 1,Interleukin-1-Like Protein 1,IL-1L1,IL36RN,FIL1D,IL1F5,IL1HY1,IL1L1,IL1RP3, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Interleukin-36 Receptor Antagonist Protein is produced by our E.coli expression system and the target gene encoding Val2-Asp155 is expressed.Accession:Q9UBH0. Expression Host:E.coli.Species:Human .Predicted Molecular Mass:16.8 KDa. Background:Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family). IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9). Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.