Recombinant Human IMPase1 (N-6His)

Description

EnkiLife provides the Recombinant Human IMPase1 (N-6His) protein,aslo know as Inositol Monophosphatase 1,IMP 1,IMPase 1,Inositol-1(or 4)-Monophosphatase 1,Lithium-Sensitive Myo-Inositol Monophosphatase A1,IMPA1,IMPA, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Inositol Monophosphatase 1 is produced by our E.coli expression system and the target gene encoding Met1-Asp277 is expressed with a 6His tag at the N-terminus.Accession:P29218. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:32.3 KDa. Background:Inositol Monophosphatase 1 (IMPA1) belongs to the inositol monophosphatase family. IMPA1 is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, IMPA1 can use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. IMPA1 has been implicated as the pharmacological target for lithium action in brain. IMPA1 shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. In addition, IMPA1 plays a improtant role in intracellular signal transduction.