Recombinant Human ITGA5 (C-6His)

Description

EnkiLife provides the Recombinant Human ITGA5 (C-6His) protein,aslo know as Integrin Alpha-5,CD49 Antigen-Like Family Member E,Fibronectin Receptor Subunit Alpha,Integrin Alpha-F,VLA-5,CD49e,ITGA5,FNRA, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Integrin α-5 is produced by our Mammalian expression system and the target gene encoding Phe42-Tyr995 is expressed with a 6His tag at the C-terminus.Accession:P08648. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:105.11 KDa. Background:Integrin α-5 belongs to the Integrin α chain family and contains 7 FG-GAP repeats. Integrin α-5 joins with Integrin-β1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions. It is expressed on fibroblasts, endothelial cells, peripheral T cells and platelets. Integrin α-5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains. In addition to adhesion, ITGA5 participates in cell-surface mediated signalling.