Recombinant Human JAG1 (C-Fc)

Description

EnkiLife provides the Recombinant Human JAG1 (C-Fc) protein,aslo know as Protein jagged-1 I,Jagged-1,JAGL1,HJ1,JAG1 and CD339, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Jagged-1 is produced by our Mammalian expression system and the target gene encoding Gln34-Ser1046 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:P78504. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:137.6 KDa. Background:Protein jagged-1 I, also known as Jagged-1, JAGL1, HJ1, JAG1 and CD339, is a single-pass type I membrane protein. JAG1 contains one DSL domain and sixteen EGF-like domain. JAG1 acts as a ligand for multiple Notch receptors and is involved in the mediation of Notch signaling. JAG1 may participate in early and late stages of mammalian cardiovascular development, JAG1 inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1 are the cause of Alagille syndrome type 1, which is autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations.