Recombinant Human JAM-B (C-6His)

Description

EnkiLife provides the Recombinant Human JAM-B (C-6His) protein,aslo know as Junctional Adhesion Molecule B,JAM-B,Junctional Adhesion Molecule 2,JAM-2,Vascular Endothelial Junction-Associated Molecule,VE-JAM,CD322,JAM2,C21orf43,VEJAM, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Junctional Adhesion Molecule B is produced by our Mammalian expression system and the target gene encoding Phe29-Asn236 is expressed with a 6His tag at the C-terminus.Accession:P57087. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:24.29 KDa. Background:Junctional Adhesion Molecule B (JAM-B) is a single-pass type I membrane protein that belongs to the juctional adhesion molecules family. JAM-B includes a signal sequence (aa 1-28), an extracellular region (aa 29-238) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (aa 239-259), and a cytoplasmic domain (aa 260 - 298). JAMB is localized to the tight junctions between endothelial cells or epithelial cells. JAM-B is prominently expressed in the heart, placenta, lung, foreskin and lymph node. It is also present on the endothelia of other vessels. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.