Recombinant Human KIR2DL1 (C-6His)

Description

EnkiLife provides the Recombinant Human KIR2DL1 (C-6His) protein,aslo know as CD158 antigen-like family member A,CD158a antigen,CD158a;KIR2DL1,MHC class I NK cell receptor,Natural killer-associated transcript 1,NKAT,NKAT-1,p58.1 MHC class-I-specific NK receptor, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Killer Cell Immunoglobulin-like Receptor 2DL1 is produced by our Mammalian expression system and the target gene encoding His22-His245 is expressed with a 6His tag at the C-terminus.Accession:P43626. Expression Host:Human cells.Species:Human.Predicted Molecular Mass:25.5 KDa. Background:Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) is an inhibitory Natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 is bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. KIR/HLA-I interactions can act through inhibition of NKC activation by target cells and NKC licensing for greater intrinsic responsiveness.