Recombinant Human KIR2DL3 (C-6His)

Description

EnkiLife provides the Recombinant Human KIR2DL3 (C-6His) protein,aslo know as Killer Cell Immunoglobulin-Like Receptor 2DL3,CD158 Antigen-Like Family Member B2,KIR-023GB,Killer Inhibitory Receptor cl 2-3,MHC Class I NK Cell Receptor,NKAT2a,NKAT2b,Natural Killer-Associated Transcript 2,NKAT-2,p58 Natural Killer Cell Receptor Clone CL-6,p58 NK Receptor CL-6,p58.2 MHC Class-I-Specific NK Receptor,CD158b2,KIR2DL3,CD158B2,KIRCL23,NKAT2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Killer Cell Immunoglobulin-like Receptor 2DL3 is produced by our Mammalian expression system and the target gene encoding His22-His245 is expressed with a 6His tag at the C-terminus.Accession:P43628. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:25.4 KDa. Background:Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.