Recombinant Human KIR2DL3 (C-Fc)

Description

EnkiLife provides the Recombinant Human KIR2DL3 (C-Fc) protein,aslo know as Killer cell immunoglobulin-like receptor 2DL3,KIR2DL3,CD158b2,NKAT2,CD158 antigen-like family member B2,KIR-023GB,Killer inhibitory receptor cl 2-3,MHC class I NK cell receptor,NKAT-2,p58 NK receptor CL-6, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Killer Cell Immunoglobulin-like Receptor 2DL3 is produced by our Mammalian expression system and the target gene encoding His22-His245 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:P43628. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:51.7 KDa. Background:Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.