Recombinant Human KIR2DL4 (C-6His)

Description

EnkiLife provides the Recombinant Human KIR2DL4 (C-6His) protein,aslo know as Killer Cell Immunoglobulin-Like Receptor 2DL4,CD158 Antigen-Like Family Member D,G9P,Killer Cell Inhibitory Receptor 103AS,KIR-103AS,MHC Class I NK Cell Receptor KIR103AS,CD158d,KIR2DL4,CD158D,KIR103AS, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Killer Cell immunoglobulin-like Receptor 2DL4 is produced by our Mammalian expression system and the target gene encoding Trp22-His242 is expressed with a 6His tag at the C-terminus.Accession:ADY38409.1. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:25.34 KDa. Background:Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.