Recombinant Human KLK3 (236AA, C-6His)

Description

EnkiLife provides the Recombinant Human KLK3 (236AA, C-6His) protein,aslo know as Prostate-specific antigen,PSA,Gamma-seminoprotein,Kallikrein-3,P-30 antigen,Semenogelase,KLK3,APS, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Kallikrein-3/Prostate-specific Antigen is produced by our Mammalian expression system and the target gene encoding Ile25-Pro261 is expressed with a 6His tag at the C-terminus.Accession:P07288. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:27.1 KDa. Background:KLK3, also known as APS, is short for Prostate-specific antigen. It is a 261 aa. protein which belongs to the peptidase S1 family and Kallikrein subfamily. This protein has 5 isforms produced by alternative splicing. It is a secreted protein and can forms a heterodimer with SERPINA5 which can inhibit its activity. KLK3 is also strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. KLK3 can hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.