Recombinant Human Latent TGF Beta-1&GARP Complex Protein (N-6His, C-3*Strep)

Description

EnkiLife provides the Recombinant Human Latent TGF Beta-1&GARP Complex Protein (N-6His, C-3*Strep) protein,aslo know as TGF Beta-1&GARP, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Latent TGF Beta-1&GARP Complex Protein is produced by our Mammalian expressionsystem and the target gene encoding Leu30-Ser390&His20-Asn627 is expressed with a 6His tag at the N-terminusand, a 3*Strep tag at the C-terminus.Accession:P01137&Q14392. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:42.1&71.0 KDa. Background:Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.