Recombinant Human LRRC15 (C-6His)

Description

EnkiLife provides the Recombinant Human LRRC15 (C-6His) protein,aslo know as Leucine-rich repeat-containing protein 15,Leucine-rich repeat protein induced by beta-amyloid homolog,LRRC15,LIB, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Leucine-rich repeat-containing protein 15 is produced by our Mammalian expression system and the target gene encoding Tyr22-Gly538 is expressed with a 6His tag at the C-terminus.Accession:Q8TF66. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:58.8 KDa. Background:The type I transmembrane protein 15-leucine-rich repeat containing membrane protein (LRRC15) is a member of the LRR superfamily. The LRR family is a structural module for protein-protein and protein-matrix interactions used for molecular recognition process such as cell adhesion, signal transduction, DNA repair, and RNA processing. The LRRC15 is also a transmembrane protein demonstrated to play important roles in cancer. LRRC15 expression was notably increased 4.6-fold in cariesdiseased pulpal tissue. Remarkably, LRRC15 was relatively abundant in mineralized tissues. That LRRC15 was significantly induced after osteogenic differentiation, while in the MSCs from bone marrow of ovariectomized mice the expression of LRRC15 was remarkably decreased and LRRC15 regulated osteogenic differentiation in a p65-dependent manner.