Recombinant Human LRRC32 (C-Fc)

Description

EnkiLife provides the Recombinant Human LRRC32 (C-Fc) protein,aslo know as GARP,GARPGarpin,Garpin,D11S833E, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Transforming Growth Factor Beta Activator LRRC32 is produced by our Mammalian expression system and the target gene encoding His20-Asn627 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q14392. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:92.9 KDa. Background:Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation. LRRC32 is widely expressed during embryogenesis and on adult platelets. Human LRRC32 is identified as a lineage specific key receptor for human T cells.