Recombinant Human MAN1B1 (C-6His)

Description

EnkiLife provides the Recombinant Human MAN1B1 (C-6His) protein,aslo know as Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase,ER Alpha-1,2-Mannosidase,ER Mannosidase 1,ERMan1,Man9GlcNAc2-Specific-Processing Alpha-Mannosidase,Mannosidase Alpha Class 1B Member 1,MAN1B1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase/MAN1B1 is produced by our Mammalian expression system and the target gene encoding Asp106-Ala699 is expressed with a 6His tag at the C-terminus.Accession:Q9UKM7. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:68.7 KDa. Background:Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.