Recombinant Human MIF(N-6His)

Description

EnkiLife provides the Recombinant Human MIF(N-6His) protein,aslo know as Macrophage migration inhibitory factor,MIF,MMIF,Glycosylation-inhibiting factor,GLIF,L-dopachrome tautomerase,Phenylpyruvate tautomerase, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Macrophage Migration Inhibitory Factor is produced by our E.coli expression system and the target gene encoding Met1-Ala115 is expressed with a 6His tag at the N-terminus.Accession:P14174. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:14.6 KDa. Background:Human MIF is a 12.5 kDa, 115 amino acid (aa) nonglycosylated polypeptide that is synthesized without asignal sequence .Secretion occurs nonclassically via an ABCA1 transporter.Pro-inflammatory cytokine.Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites ofinflammation suggests a role as mediator in regulating the function of acrophages in host defense.Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase anddopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clearwhether the tautomerase activity has any physiological relevance, and whether it is important for cytokineactivity.