Recombinant Human MMP-8 (C-10His)

Description

EnkiLife provides the Recombinant Human MMP-8 (C-10His) protein,aslo know as Neutrophil collagenase,Matrix metalloproteinase-8,MMP-8,PMNL collagenase,PMNL-CL,MMP8,CLG1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Neutrophil Collagenase is produced by our Mammalian expression system and the target gene encoding Phe21-Gly467 is expressed with a 10His tag at the C-terminus.The proenzyme needs to be activated by APMA for an activated form.Accession:P22894. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:52.8 KDa. Background:Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP8(neutrophil collagenase) is expressed in neutrophils, where it is stored in specific granules. MMP8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8, TNF-α and GM-CSF. MMP8 is capable of cleaving types I, II and III triple-helical collagen, gelatin peptides, fibronectin, proteoglycans, aggrecan, serpins, β-casein and peptides such as angiotensin and substance P. In addition to its function in phagocytosis, MMP8 has a high capacity for infiltrating connective tissue, and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis. MMP8 is heavily glycosylated.