Recombinant Human Mucin-17 (C-6His)

Description

EnkiLife provides the Recombinant Human Mucin-17 (C-6His) protein,aslo know as Mucin-17, MUC-17, MUC17, MUC3, MUC-3, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Mucin-17 is produced by our Mammalian expression system and the target gene encoding Arg4131-Leu4390 is expressed with a 6His tag at the C-terminus.Accession:Q685J3. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:30.1 kDa. Background:Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for patients. And that p38 signalling is a key factor involved in MUC17-mediated inhibition of GC cell proliferation and protection against inflammatory stimulation, MUC17 upregulates the expression of MYH9 and p53, and activates the p38 pathway in GC cells through RhoA signalling.