Recombinant Human NEDD8

Description

EnkiLife provides the Recombinant Human NEDD8 protein,aslo know as Neural precursor cell expressed developmentally down-regulated protein 8,NEDD8,Neddylin,Ubiquitin-like protein Nedd8, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Neural precursor cell expressed developmentally down-regulated protein 8 is produced by our E.coli expression system and the target gene encoding Met1-Gly76 is expressed.Accession:Q15843. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:8.6 KDa. Background:Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.