Recombinant Human NFKB1 (N-6His)

Description

EnkiLife provides the Recombinant Human NFKB1 (N-6His) protein,aslo know as DNA-binding factor KBF1,EBP-1,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Nuclear Factor NF-kappa-B P50 Subunit is produced by our E.coli expression system and the target gene encoding Met1-Gly434 is expressed with a 6His tag at the N-terminus.Accession:P19838-2. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:49.7 KDa. Background:The 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.