Recombinant Human NKp44 (C-6His)

Description

EnkiLife provides the Recombinant Human NKp44 (C-6His) protein,aslo know as CD336 Protein,dJ149M18.1 Protein,LY95 Protein,NK-p44 Protein,NKP44 Protein,RP1-149M18.2 Protein, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Natural cytotoxicity triggering receptor 2 is produced by our Mammalian expression system and the target gene encoding Gln22-Pro190 is expressed with a 6His tag at the C-terminus.Accession:O95944. Expression Host:Human Cells.Species:Human.Predicted Molecular Mass:19.4 KDa. Background:Natural cytotoxicity triggering receptor 2 (NCR2), also known as Natural killer cell p44-related protein (NKp44), or CD336, is a member of the natural cytotoxicity receptor (NCR) family, which composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. It is a novel transmembrane glycoprotein belonging to the Immunoglobulin superfamily characterized by a single extracellular V-type domain. The cytoplasmic domain of NKp44 also contains a sequence that matches the immunoreceptor tyrosine-based inhibitory motif (ITIM) consensus. This Cytotoxicity-activating receptor may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. NKp44 is selectively expressed by IL-2-activated NK cells and may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis. Tumor cell recognition of the mutated NKp44 proteins was significantly reduced and correlated with their lower recognition of heparin.