Recombinant Human NRG1Beta (71AA)

Description

EnkiLife provides the Recombinant Human NRG1Beta (71AA) protein,aslo know as Pro-neuregulin-1,Neuregulin-1 beta 1,NRG1-beta 1,HRG1-beta 1,EGF;NRG1,GGF,HGL,HRGA,NDF,SMDF, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human Neuregulin-1 Beta is produced by our E.coli expression system and the target gene encoding Thr176-Lys246 is expressed.Accession:Q02297-6. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:8.2 KDa. Background:neuregulin-1 (heregulin-1，NRG1) is a member of neuregulin family, which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.