Recombinant Human OGG1

Description

EnkiLife provides the Recombinant Human OGG1 protein,aslo know as N-Glycosylase/DNA Lyase,8-Oxoguanine DNA Glycosylase,DNA-(Apurinic or Apyrimidinic Site) Lyase,AP Lyase,OGG1,MMH,MUTM,OGH1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Human N-Glycosylase is produced by our E.coli expression system and the target gene encoding Met1-Gly345 is expressed.Accession:AAH00657.1. Expression Host:E.coli.Species:Human.Predicted Molecular Mass:38.8 KDa. Background:Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.